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4D Nucleome
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2026 3 months ago
Strands of DNA-like thread coil, loop, and spill upward, evoking the genome's dynamic three-dimensional architecture within the nucleus of a living cell.
This special issue, with papers in Science and Science Advances, features single-cell and multiomic studies from the National Institutes of Health Common Fund's 4D Nucleome Program, which examines a fourth dimension of nuclear organization—how this folded structure shapes cell identity, shifts across development and aging, and goes awry in disease.
Researchers mapped genome architecture across contexts ranging from the aging and Alzheimer's-affected brain to the failing heart and maturing immune cells, alongside new computational tools for reading this architecture in previously understudied tissue.
Learn more: https://scim.ag/4htc3UT
ILLUSTRATION CREDIT: A. FISHER/SCIENCE
#Science #ScienceAdvances #ScienceShorts
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